All organisms must coordinate a phenomenal array of highly interconnected metabolic processes to efficiently obtain and use resources in order to maximize their fitness. This intricate coordination of biological processes relies on naturally variable regulatory networks likely reflecting an adaptation to survival in different environments.
We exploit the naturally variation in glucosinolate profiles in Arabidopsis and the regulatory networks that shape these profiles to elucidate new network components. Although we have identified nearly all of the major genes controlling natural variation in glucosinolates in the past decade, there are hundreds of additional genes that remain to be studied.
Most of these have very modest or conditional effects that complicate their identification, but their identification will be critical to understand the glucosinolate regulatory network and its interconnectivity to networks controlling general metabolic and developmental processes.
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Francisco M, Joseph B, Caligagan H, Li B, Corwin JA, Lin C, Kerwin RE, Burow M, Kliebenstein DJ (2016) Genome wide association mapping in Arabidopsis thaliana identifies novel genes involved in linking allyl glucosinolate to altered biomass and defense. Frontiers in plant science 7: 1010. DOI:10.3389/fpls.2016.01010
Francisco M, Joseph B, Caligagan H, Li B, Corwin JA, Lin C, Kerwin R, Burow M, Kliebenstein DJ (2016) The defense metabolite, allyl glucosinolate, modulates Arabidopsis thaliana biomass dependent upon the endogenous glucosinolate pathway. Frontiers in plant science 7: 774. DOI:10.3389/fpls.2016.00774
Jensen LM, Jepsen HSK, Halkier BA, Kliebenstein DJ, Burow M (2015) Natural variation in cross-talk between glucosinolates and onset of flowering in Arabidopsis. Front Plant Sci 6: 697. DOI:10.3389/fpls.2015.00697
Jensen LM, Kliebenstein DJ, Burow M (2015) Investigation of the multifunctional gene AOP3 expands the regulatory network fine-tuning glucosinolate production in Arabidopsis. Frontiers in Plant Science 6:762. DOI:10.3389/fpls.2015.00762
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