Regulatory networks cannot be fully described only by identifying the genes involved because they consist of many different kinds of molecules; metabolites, RNAs, proteins, and enzymes. All of these interact which each other to fine-tune the metabolism of an organism.
Currently, more and more regulatory RNAs of variable length are being added to the catalogue of regulatory network components. This includes small regulatory RNAs (e.g. miRNAs) and long regulatory RNAs (e.g. lncRNAs) that exert their action mainly or exclusively at the RNA level to regulate gene expression at the post-transcriptional level.
Both miRNAs and long regulatory RNAs play a role in the fine-tuning glucosinolate profiles and in linking the glucosinolate pathway to developmental processes. We study these regulatory RNAs in vivo and to identify their targets and to unravel this additional layer of post-transcriptional regulation of plant defenses.
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Jensen LM, Kliebenstein DJ, Burow M (2015) Investigation of the multifunctional gene AOP3 expands the regulatory network fine-tuning glucosinolate production in Arabidopsis. Front Plant Sci 6: 762. DOI:10.3389/fpls.2015.00762
Burow M, Atwell S, Francisco M, Kerwin RE, Halkier BA, Kliebenstein DJ (2015) The glucosinolate biosynthetic gene AOP2 mediates feed-back regulation of jasmonic acid signaling in Arabidopsis. Molecular Plant 8:1201-12. DOI:10.1016/j.molp.2015.03.001
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