13 July 2018

Dynamic modelling of indole glucosinolate hydrolysis and its impact on auxin signaling

Daniel Vik, Namiko Mitarai, Nikolai Wulff, Barbara Ann Halkier, Meike Burow
Frontiers in Plant Science. doi: 10.3389/fpls.2018.00550.

Arabidopsis thaliana relies on multiple defense compounds, including indol-3-ylmethyl glucosinolate (I3G), which upon hydrolysis initiated by myrosinase enzymes releases a multitude of bioactive compounds, initially, either indole-3-acetonitrile (IAN) or indole-3-acetoisothiocyanate (ITC). Using mathematical modelling, we simulated potential signaling events upon I3G hydrolysis during herbivore attack and I3G turnover in intact tissue and found that each scenario gives rise to distinct auxin signaling dynamics.