Welcome to Caroline!
On 1 January 2024, Caroline Marcher Holm started as a PhD student at DynaMo Center as part of the Novo Nordisk Foundation exploratory synergy grant on Leveraging plant transportomics headed by Assoc. prof Hussam Nour-Eldin in collaboration with Henrik Dimke at University of Southern Denmark.
The focus of Carolines project is to characterize the substrate spectrum of the human ABCC-transporter family using a novel interdisciplinary approach.
Caroline will use Xenopus laevis oocytes as expression system to develop a novel untargeted experimental approach to assign substrates to ABCC-members. Physiological roles will be characterized in mouse models.
Caroline is trained in ion channel electrophysiology and did her MSc in 2023 at the Health Faculty of University of Copenhagen. Her MSc project focused on acid-sensing ion channels, and she combined electrophysiology and fluorometry to gain functional and dynamic information simultaneously. For this purpose, she used a mutational and pharmacological approach to modulate the channel properties of ASIC1a expressed in Xenopus laevis oocytes.
Caroline will be supervised by DynaMo Partner and Associate Professor Hussam Nour-Eldin and partly by Associate Professor Henrik Dimke at University of Southern Denmark.